Functional Brain Connectivity during Emotion Regulation and Applications to Bipolar Disorder

............................................................................................................... ii Acknowledgements .............................................................................................. viii Vita ....................................................................................................................... x Chapter 1: Introduction............................................................................................... 1 Chapter 2: Uncovering early and late stage activity during the cognitive reappraisal of emotion............................................................................... 12 Chapter 3: Early and late stage activation differences during reappraisal in bipolar disorder......................................................................................... 31 Chapter 4: Advancing understanding of affect labeling with dynamic causal modeling........................................................................... 39 Chapter 5: Effective connectivity differences in bipolar disorder during affect labeling................................................................................. 65 Chapter 6: Differences in Resting Corticolimbic Functional Connectivity in Bipolar I Euthymia.................................................................................. 74 Chapter 7: Summary and discussion........................................................................... 94 Appendix 1: Seven major Matlab scripts ....................................................................... 99 Appendix 2: A between-group DCM protocol................................................................ 109 References........................................................................................................... 111